Hi Rob,
We have the MOM for hardware remote control, this has an external jack input that can be set up to control fe.x. a mute in your Profile..
Reg software control: As it stands we are using EuCon for all control and integration.
Obviously, that is somewhat limited to the Pro Tools ecosystem.
Your question is a much requested feature in our world and we are always looking at how to make happy customers.
Best,
Jon